New Generation Disinfecting Products
Today, the general amount of applied disinfectants, out in the world markets are more or less toxic, possess carcinogenic properties and are not safe for humans. And continuous use, can cause allergies and even poisoning.
Our New Generation organic disinfectant "NCare Silver", was developed, using the most advanced achievements in Nanotechnology and is effective against Corona Virus, Ebola, HIV, SARS-COV2, and does not have such disadvantages that comes with regular disinfectants and Sanitizers.
It can be supplied in the form of aqueous solution of disinfectant concentrate in following composition:
- Silver citrate 500 mg/liter;
- Copper citrate 500 mg/liter.
It can also be diluted with a concentrate of 3% -10% working solution , mixed with demineralized water.
Our Organic hand Sanitizer "NCare Silver" for the treatment of open areas of hands & body, can be supplied in a ready-to-use composition in the form of aqueous solution:
- Silver citrate 35 mg/liter;
- Copper citrate 35 mg/liter;
- Magnesium citrate 35 mg/liter;
- Zinc citrate 35 mg/liter;
- Germanium citrate 35 mg/liter.
The general advantages of our disinfecting products over those on the market are as follows:
- Environmentally friendly;
- Do not have carcinogenic properties;
- Non-toxic to humans and pets when inhaled, swallowed, contact with mucous
Membranes.
-And allow disinfection without protective equipment, like PPE;
- Has no bad smell;
- Suitable for repeated use, each subsequent treatment enhances the effect of
Disinfection;
- Does not dry up the skin;
- Helps to strengthen human immune system;
- Destroy more than 1000 types of pathogenic microorganisms (pathogenic
viruses, bacteria and fungi);
- Destroy coronavirus in 30 seconds (confirmed by Certified independent
laboratories);
- Does not contain Nanoparticles that contribute to the oncological diseases,
which is typical for colloidal solutions based on Nanosilver;
-Our Sanitizers are characterized by high stability. Which allows to increase
the shelf life for up to 3 years;
-Safe for any means of transportation.
-Effect remains on the skin for a minimum period of 24 hours. Thereby
Protecting you all day, and subsequently saving you a whole lot of money
Compared to other peculiar products in the market.
Innovative technologies for the production of active substances that make up the basis of the preparations, makes it possible to obtain the following unique properties of disinfectants and new mechanisms of action on viruses that do not have any analogues known in the world market.
«Trojan horse»
The essence of the new mechanism of the effect of Silver and Copper citrate particles on viruses, including the COVID-19 Corona Virus called the "Trojan Horse", is as follows: The virus, like any other biological object, identifies any citrate, which is an organic compound, not as a foreign object that must be “feared” but on the contrary , as a bioavailable substance that can potentially give an impulse to development. Therefore, the virus very easily "captures" the molecule of citrate, not distinguishing that Silver or Copper can be dangerous for its existence. And at the end , the virus is destroyed. Copper is a synergist of Silver, therefore it enhances the antiviral properties of disinfectant.
«Silver-Copper Trap»
The overwhelming majority of disinfectants, including alcohol and chlorine based, have a short-term effect, because immediately after evaporation of the liquid phase their antiviral effect disappears.
Disinfectants based on Silver and Copper citrates have a double antiviral effect, namely, they have not only a short-term, but also prolonged action. After evaporation of the liquid phase, they retain their antiviral properties for a long time due to the fact that particles of Silver and Copper remain on the treated surface. These particles, like a trap, waits for the appearance of viruses and destroy them immediately after they appear on a previously treated surface. So, for example, when treating hands, a person,is considered as good as wearing "invisible anti-virus gloves" for 24 hours. When the virus gets on these "gloves", it is destroyed. And subsequently, the chain of further transmission of viruses from unwashed hands to the mucous membranes of the human T-zone (eyes, mouth, nose) is interrupted. A similar effect takes place when processing hard surfaces of the interior of closed rooms with our NCare Disinfectant, which, as it were, are covered with an invisible protective film and when it gets on - the virus is destroyed, and effect remains for a minimum of 24 hours.
«Electrostatic Virus Inactivator»
The peculiarity of the charges of virus particles and cell receptors is that the force of their attraction is 1042 times greater than the force of gravity. This is the main reason for the rapid spread of viral infections associated with the COVID-19 coronavirus. Due to the inclusion of Copper with a low oxidation state in the composition of our products, it suppresses the adsorption activity of viruses, as the force of their attraction to the cell disappears. This new mechanism of action on viruses is the most effective, because it has an electrostatic, but not a toxic nature, unlike every other typical disinfectants on the market.
INFORMATION
“Some Features of Silver Based Disinfectants AND Antiseptic” ”
The pandemic caused by the coronavirus COVID-19 has led to the widespread implementation of disinfection measures unprecedented in scale and an avalanche-like increase in the production of various types of disinfectants. Practice has shown that a high demand and lack of proper government control in many countries of the world, unfortunately, often leads to the cases when ineffective disinfectants are used. Moreover, such cases are not always associated with low competence of business management, and in many cases have a corruptive nature and cause criminal consequences, especially when has a direct threat to the health and life of a large number of people.
The aim of our analysis is the study of some of the peculiarities of Silver based disinfectants , which have recently begun to be widely used in various spheres of human activity. They have great prospects for application, namely, because of the use of the latest technologies for obtaining active substances of a new generation, which gives disinfectants other qualitative characteristics in comparison with other products in the market, that are alcohol and chlorine based, compounds. Disinfection solutions, where silver is an active substance, can be divided into three groups.
The first group includes disinfectants containing silver salts. The most common of them is silver nitrate.
The second group includes disinfectants, where colloid silver is the active substance, as well as silver nanoparticles.
The third group includes disinfectants based on silver citrates.
The effectiveness of the use of all these drugs, as a rule, is enhanced by other active substances, such as, for example, hydrogen peroxide, alcohol, food acids.
Disinfectants of the first group, based on silver salts, including silver nitrate, have been known for a long time, but have not found widespread use due to their low efficiency. If they are mixed with hydrogen peroxide, then it performs the function of the main active substance. Thus, silver in nitrate form has low bioavailability and does not have a pronounced antibacterial and antiviral properties, that’s why it doesn’t show significant effects on basic functional properties of drugs.
Several Indian companies make disinfectants based on hydrogen peroxide and silver nitrate. The cost of the finished product is about $4/liter.
Nanotechnologies has opened wider possibilities for the production of new generation disinfectants using silver, and at present time there are several types of such disinfectants of this production method on the world market, which can be attributed to the second and third groups.
The second group of solution is obtained using outdated technologies of an unfinished cycle, where final product is the active substance in the form of silver nanoparticles. They can be used alone or in combination with other active ingredients. Most common of them is a combination of silver nanoparticles with hydrogen peroxide or alcohol.
Currently, the process of obtaining nanoparticles of silver or nanoparticles of any other metal is quite simple. However, the use of pure nanoparticles, including silver nanoparticles, is unsafe for humans and animals. This is due to the fact that nanomaterials have a biological effect and a complex of physical and chemical properties, which often radically differ from the properties of the same substance in the form of continuous phases or macroscopic dispersions (1).
In the nanosized state, the following physicochemical features of nanoparticles behavior should be distinguished:
1) an increase in the chemical potential of substances leads to significant changes in the solubility, reactive and catalytic ability of nanoparticles and their components;
2) a large specific surface area of nanoparticles increases their adsorption capacity, chemical reactivity and catalytic properties, leads to an increase in the production of free radicals and reactive oxygen forms, and the destruction of biological structures;
3) small size and diversity of nanoparticles give them opportunity to bind to nucleic acids, proteins embedded in the membrane, penetrate the cell organelles and thereby alter the function of biological structures;
4) high adsorption activity due to the developed surface of nanoparticles gives them the properties of an effective sorbent and the ability to absorb many times more substances per unit mass in comparison with macroscopic dispersions;
5) high ability of nanoparticles to accumulation.
It is clear that nanoparticles with the earlier mentioned physicochemical properties and the indicated biological action are completely new types of materials in comparison with traditional analogs. Therefore, silver nanoparticles can penetrate even through respirators into the human body who treats the room with such disinfectants. Also, there is a high possibility that remaining after processing on surfaces of solid interior space, they can also cause effects in accordance with the mechanisms described above in paragraphs 2, 3.
Thus, determination of potential risk to human health and life is required prior the application of disinfectants from the second group, where silver nanoparticles are active substances.
A significant drawback of drugs of the second group is due to the peculiarities of the nanoparticles noted in paragraphs 1, 4, 5.
Thus, not stabilized silver nanoparticles come into uncontrolled reaction with any other molecules of aqueous medium or air, forming different insoluble compounds which tend to accumulation. In this case, the formation of large structures takes place, incommensurate with nano sizes, that have non-deterministic chemical composition. Therefore, due to the possibility of the formation of other compounds based on silver nanoparticles and the uneven distribution of silver as an active substance on the treated surface, its effectiveness as an antiviral component is significantly reduced. Below you can see photograph of a disinfectant in which silver nanoparticles are used as an active ingredient after 4 days of storage in daylight.
One can observe a change in color of the preparation and a significant size of macroscopic formations based on silver nanoparticles.
The low efficiency of drugs using silver nanoparticles was confirmed during comparative tests of disinfectants at the Institute of Epidemiology and Infectious Diseases named after V.L. Gromashevsky National Academy of Medical Sciences of Ukraine. The virucidal activity of existing disinfecting drugs on the Ukrainian market was investigated: "Sumerian Silver", "ISeS", "ARGUMIN", "BACTRILON A" (BAA-G), "Polidez" on the model of coronavirus of transmissible gastroenteritis of pigs (TGS).
Fig 1. Photo of Argumin after 4 days in the sun
For disinfecting drugs of the second group relates disinfectant «ARGUMIN», which is a colloidal solution of silver nanoparticles in demineralized water.
A fragment of the report is presented below.
Determination of the effect of Solution "Sumerian Silver", "ISeS" , "ARGUMIN" , "BACTRILON A" (BAA-T), "Polidez" for extracellular coronavirus TGS was examined as follows: to a suspension of coronavirus TGS in a dose of 1000 TCD50/ ml was added solution "Sumerian Silver", "ISeS", "ARGUMIN", "BACTRILON A" "Polidez" diluted 1:1000 were incubated at room temperature and were sampled in noncellular virus after 5 min and 20 min.
The results of determining the effect of drugs on extracellular coronavirus TGS are shown in Fig.2.
Fig. 2 Infectious titer of the TGS virus in the wells treated with the virus
TGS 1000 ID50 and drugs
According to the obtained results, it was found that the disinfectants " Sumerian Silver", "BACTRILON A" (BAD-G), "Polidez" inhibited the reproduction of the extracellular coronavirus TGS by 2.0 lgID50 with an exposure of 30 minutes, and "ARGUMIN" only for 1.0 lgID50. A decrease in the infectious titer of the virus by 1.5-2.0 lgID50 and more in comparison with the control of the substance with the virus indicates the severity of the virucidal effect.
Thus, the disinfectant with silver nanoparticles does not have sufficient antiviral properties.
For this research was chosen one of silver nanoparticles disinfectants available on the market. Undoubtedly, similar results will be obtained for other disinfectants that use silver nanoparticles as active substances.
Unfortunately, many companies do not provide information on the chemical form in which silver is present in the preparation. For example, the American company “xxx” ™ is one example. Its composition is represented by the following active ingredients:
Hydrogen peroxide ………....5,00%
Silver ……………………… 0.01%